JURJ

Chalcone Affiliates : Significance in Antineoplastic Therapy

Author: Sumita Kumari , Dr Amit Sharma , Dr Sonia Yadav

Abstract:

Cancer is most serious public health issue and lead by numerous factors. Chalcones are the building blocks of several heterocyclic componds and flavonoids. These compounds are advantageous due to their least side effects, simple structural modifications, easy availability, many biological features. Furthermore, for discovery of new anticancer drugs, chalcones serves as precursor or starting point. Both synthetic and natural chalcones produce anticancer effects in-vitro and in-vivo. Tubulin inhibition is most important mechanism of action of anticancer activity of chalcones. For efficient activity, chalcone hybridization with cancer pharmacophore is favourable. For example, coumarin conjugation with chalcone lead increase in pharmacological properties and can improve or change lipophilic character or parameters.

Keywords: Cancer, Cell lines, Tubulin inhibition, MDR inhibition, Chalcone